Abstract
Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
Original language | English |
---|---|
Pages (from-to) | 743-800 |
Number of pages | 58 |
Journal | Lancet |
Volume | 386 |
Issue number | 9995 |
DOIs | |
State | Published - 2015/08/22 |
ASJC Scopus subject areas
- General Medicine
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Vos, T., Barber, R. M., Bell, B., Bertozzi-Villa, A., Biryukov, S., Bolliger, I., Charlson, F., Davis, A., Degenhardt, L., Dicker, D., Duan, L., Erskine, H., Feigin, V. L., Ferrari, A. J., Fitzmaurice, C., Fleming, T., Graetz, N., Guinovart, C., Haagsma, J., ... Murray, C. J. L. (2015). Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet, 386(9995), 743-800. https://doi.org/10.1016/S0140-6736(15)60692-4
Vos, Theo ; Barber, Ryan M. ; Bell, Brad et al. / Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013 : A systematic analysis for the Global Burden of Disease Study 2013. In: Lancet. 2015 ; Vol. 386, No. 9995. pp. 743-800.
@article{665427cc7e6942c183496e3ec9c4f59e,
title = "Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013",
abstract = "Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.",
author = "Theo Vos and Barber, {Ryan M.} and Brad Bell and Amelia Bertozzi-Villa and Stan Biryukov and Ian Bolliger and Fiona Charlson and Adrian Davis and Louisa Degenhardt and Daniel Dicker and Leilei Duan and Holly Erskine and Feigin, {Valery L.} and Ferrari, {Alize J.} and Christina Fitzmaurice and Thomas Fleming and Nicholas Graetz and Caterina Guinovart and Juanita Haagsma and Hansen, {Gillian M.} and Hanson, {Sarah Wulf} and Heuton, {Kyle R.} and Hideki Higashi and Nicholas Kassebaum and Hmwe Kyu and Evan Laurie and Xiofeng Liang and Katherine Lofgren and Rafael Lozano and MacIntyre, {Michael F.} and Maziar Moradi-Lakeh and Mohsen Naghavi and Grant Nguyen and Shaun Odell and Katrina Ortblad and Roberts, {David Allen} and Roth, {Gregory A.} and Logan Sandar and Serina, {Peter T.} and Stanaway, {Jeffrey D.} and Caitlyn Steiner and Bernadette Thomas and Vollset, {Stein Emil} and Harvey Whiteford and Wolock, {Timothy M.} and Pengpeng Ye and Maigeng Zhou and {\~A}vila, {Marco A.} and Aasvang, {Gunn Marit} and Cristiana Abbafati and Ozgoren, {Ayse Abbasoglu} and Foad Abd-Allah and Aziz, {Muna I.Abdel} and Abera, {Semaw F.} and Victor Aboyans and Abraham, {Jerry P.} and Biju Abraham and Ibrahim Abubakar and Abu-Raddad, {Laith J.} and Abu-Rmeileh, {Niveen M.E.} and Aburto, {Tania C.} and Tom Achoki and Ackerman, {Ilana N.} and Ademola Adelekan and Zanfina Ademi and Adou, {Ars{\`e}ne K.} and Adsuar, {Josef C.} and Johan Arnlov and Agardh, {Emilie E.} and {Al Khabouri}, {Mazin J.} and Alam, {Sayed Saidul} and Deena Alasfoor and Albittar, {Mohammed I.} and Alegretti, {Miguel A.} and Aleman, {Alicia V.} and Alemu, {Zewdie A.} and Rafael Alfonso-Cristancho and Samia Alhabib and Raghib Ali and Francois Alla and Peter Allebeck and Allen, {Peter J.} and AlMazroa, {Mohammad Abdulaziz} and Ubai Alsharif and Elena Alvarez and Nelson Alvis-Guzman and Omid Ameli and Heresh Amini and Walid Ammar and Anderson, {Benjamin O.} and Anderson, {H. Ross} and Antonio, {Carl Abelardo T.} and Palwasha Anwari and Henry Apfel and Arsenijevic, {Valentain S.Arsic} and Al Artaman and Asghar, {Rana J.} and Reza Assadi and Atkins, {Lydia S.} and Charles Atkinson and Alaa Badawi and Bahit, {Maria C.} and Talal Bakfalouni and Kalpana Balakrishnan and Shivanthi Balalla and Amitava Banerjee and Barker-Collo, {Suzanne L.} and Simon Barquera and Lars Barregard and Barrero, {Lope H.} and Sanjay Basu and Arindam Basu and Amanda Baxter and Justin Beardsley and Neeraj Bedi and Ettore Beghi and Tolesa Bekele and Bell, {Michelle L.} and Corina Benjet and Bennett, {Derrick A.} and Bensenor, {Isabela M.} and Habib Benzian and Eduardo Bernabe and Beyene, {Tariku J.} and Neeraj Bhala and Ashish Bhalla and Zulfiqar Bhutta and Kelly Bienhoff and Boris Bikbov and Abdulhak, {Aref Bin} and Blore, {Jed D.} and Blyth, {Fiona M.} and Bohensky, {Megan A.} and Basara, {Berrak Bora} and Guilherme Borges and Bornstein, {Natan M.} and Dipan Bose and Soufiane Boufous and Bourne, {Rupert R.} and Boyers, {Lindsay N.} and Michael Brainin and Michael Brauer and Brayne, {Carol E.G.} and Alexandra Brazinova and Breitborde, {Nicholas J.K.} and Hermann Brenner and Briggs, {Adam D.M.} and Brooks, {Peter M.} and Jonathan Brown and Brugha, {Traolach S.} and Rachelle Buchbinder and Buckle, {Geoffrey C.} and Gene Bukhman and Bulloch, {Andrew G.} and Michael Burch and Richard Burnett and Rosario Cardenas and Cabral, {Norberto L.} and Campos-Nonato, {Ismael R.} and Campuzano, {Julio C.} and Carapetis, {Jonathan R.} and Carpenter, {David O.} and Valeria Caso and Castaneda-Orjuela, {Carlos A.} and Ferran Catala-Lopez and Chadha, {Vineet K.} and Chang, {Jung Chen} and Honglei Chen and Wanqing Chen and Chiang, {Peggy P.} and Odgerel Chimed-Ochir and Rajiv Chowdhury and Hanne Christensen and Christophi, {Costas A.} and Chugh, {Sumeet S.} and Massimo Cirillo and Megan Coggeshall and Aaron Cohen and Valentina Colistro and Colquhoun, {Samantha M.} and Contreras, {Alejandra G.} and Cooper, {Leslie T.} and Cyrus Cooper and Kimberly Cooperrider and Josef Coresh and Monica Cortinovis and Criqui, {Michael H.} and Crump, {John A.} and Lucia Cuevas-Nasu and Rakhi Dandona and Lalit Dandona and Emily Dansereau and Dantes, {Hector G.} and Dargan, {Paul I.} and Gail Davey and Davitoiu, {Dragos V.} and Anand Dayama and {De La Cruz-Gongora}, Vanessa and {De La Vega}, {Shelley F.} and {De Leo}, Diego and {Del Pozo-Cruz}, Borja and Dellavalle, {Robert P.} and Kebede Deribe and Sarah Derrett and {Des Jarlais}, {Don C.} and Muluken Dessalegn and DeVeber, {Gabrielle A.} and Dharmaratne, {Samath D.} and Cesar Diaz-Torne and Ding, {Eric L.} and Klara Dokova and Dorsey, {E. R.} and Driscoll, {Tim R.} and Herbert Duber and Durrani, {Adnan M.} and Edmond, {Karen M.} and Ellenbogen, {Richard G.} and Matthias Endres and Ermakov, {Sergey P.} and Babak Eshrati and Alireza Esteghamati and Kara Estep and Saman Fahimi and Farshad Farzadfar and Fay, {Derek F.J.} and Felson, {David T.} and Fereshtehnejad, {Seyed Mohammad} and Fernandes, {Jefferson G.} and Ferri, {Cluesa P.} and Abraham Flaxman and Nataliya Foigt and Foreman, {Kyle J.} and Fowkes, {F. 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Dean} and Mazeda Hossain and Hotez, {Peter J.} and Hoy, {Damian G.} and Mohamed Hsairi and Howard Hu and Guoqing Hu and Huang, {John J.} and Cheng Huang and Laetitia Huiart and Abdullatif Husseini and Marissa Iannarone and Iburg, {Kim M.} and Kaire Innos and Manami Inoue and Jacobsen, {Kathryn H.} and Jassal, {Simerjot K.} and Panniyammakal Jeemon and Jensen, {Paul N.} and Vivekanand Jha and Guohong Jiang and Ying Jiang and Jonas, {Jost B.} and Jonathan Joseph and Knud Juel and Haidong Kan and Andre Karch and Chante Karimkhani and Ganesan Karthikeyan and Ronit Katz and Anil Kaul and Norito Kawakami and Kazi, {Dhruv S.} and Kemp, {Andrew H.} and Kengne, {Andre P.} and Khader, {Yousef S.} and Khalifa, {Shams Eldin A.H.} and Khan, {Ejaz A.} and Gulfaraz Khan and Khang, {Young Ho} and Irma Khonelidze and Christian Kieling and Daniel Kim and Sungroul Kim and Kimokoti, {Ruth W.} and Yohannes Kinfu and Kinge, {Jonas M.} and Kissela, {Brett M.} and Miia Kivipelto and Luke Knibbs and Knudsen, {Ann Kristin} and Yoshihiro Kokubo and Soewarta Kosen and Alexander Kramer and Michael Kravchenko and Krishnamurthi, {Rita V.} and Sanjay Krishnaswami and Defo, {Barthelemy Kuate} and Bicer, {Burcu Kucuk} and Kuipers, {Ernst J.} and Kulkarni, {Veena S.} and Kaushalendra Kumar and Kumar, {G. 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M.Venkat} and Denis Nash and Chakib Nejjari and Neupane, {Sudan P.} and Newman, {Lori M.} and Newton, {Charles R.} and Marie Ng and Ngalesoni, {Frida N.} and Nhung, {Nguyen T.} and Nisar, {Muhammad I.} and Sandra Nolte and Norheim, {Ole F.} and Norman, {Rosana E.} and Bo Norrving and Luke Nyakarahuka and Oh, {In Hwan} and Takayoshi Ohkubo and Omer, {Saad B.} and Opio, {John Nelson} and Alberto Ortiz and Pandian, {Jeyaraj D.} and Panelo, {Carlo Irwin A.} and Christina Papachristou and Park, {Eun Kee} and Parry, {Charles D.} and Caicedo, {Angel J.Paternina} and Patten, {Scott B.} and Paul, {Vinod K.} and Pavlin, {Boris I.} and Neil Pearce and Pedraza, {Lilia S.} and Pellegrini, {Carlos A.} and Pereira, {David M.} and Perez-Ruiz, {Fernando P.} and Norberto Perico and Aslam Pervaiz and Konrad Pesudovs and Peterson, {Carrie B.} and Max Petzold and Phillips, {Michael R.} and David Phillips and Bryan Phillips and Piel, {Frederic B.} and Dietrich Plass and Dan Poenaru and Polanczyk, {Guilherme V.} and Suzanne Polinder and Pope, {C. 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Ryan} and Ronny Westerman and Wilkinson, {James D.} and Williams, {Hywel C.} and Williams, {Thomas N.} and Woldeyohannes, {Solomon M.} and Wolfe, {Charles D.A.} and Wong, {John Q.} and Haidong Wong and Woolf, {Anthony D.} and Wright, {Jonathan L.} and Brittany Wurtz and Gelin Xu and Gonghuan Yang and Yuichiro Yano and Yenesew, {Muluken A.} and Yentur, {Gokalp K.} and Paul Yip and Naohiro Yonemoto and Yoon, {Seok Jun} and Mustafa Younis and Chuanhua Yu and Kim, {Kim Yun} and Zaki, {Maysaa El Sayed} and Yong Zhang and Zheng Zhao and Yong Zhao and Jun Zhu and David Zonies and Zunt, {Joseph R.} and Salomon, {Joshua A.} and Murray, {Christopher J.L.}",
note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",
year = "2015",
month = aug,
day = "22",
doi = "10.1016/S0140-6736(15)60692-4",
language = "英語",
volume = "386",
pages = "743--800",
journal = "Lancet",
issn = "0140-6736",
publisher = "Elsevier Ltd.",
number = "9995",
}
Vos, T, Barber, RM, Bell, B, Bertozzi-Villa, A, Biryukov, S, Bolliger, I, Charlson, F, Davis, A, Degenhardt, L, Dicker, D, Duan, L, Erskine, H, Feigin, VL, Ferrari, AJ, Fitzmaurice, C, Fleming, T, Graetz, N, Guinovart, C, Haagsma, J, Hansen, GM, Hanson, SW, Heuton, KR, Higashi, H, Kassebaum, N, Kyu, H, Laurie, E, Liang, X, Lofgren, K, Lozano, R, MacIntyre, MF, Moradi-Lakeh, M, Naghavi, M, Nguyen, G, Odell, S, Ortblad, K, Roberts, DA, Roth, GA, Sandar, L, Serina, PT, Stanaway, JD, Steiner, C, Thomas, B, Vollset, SE, Whiteford, H, Wolock, TM, Ye, P, Zhou, M, Ãvila, MA, Aasvang, GM, Abbafati, C, Ozgoren, AA, Abd-Allah, F, Aziz, MIA, Abera, SF, Aboyans, V, Abraham, JP, Abraham, B, Abubakar, I, Abu-Raddad, LJ, Abu-Rmeileh, NME, Aburto, TC, Achoki, T, Ackerman, IN, Adelekan, A, Ademi, Z, Adou, AK, Adsuar, JC, Arnlov, J, Agardh, EE, Al Khabouri, MJ, Alam, SS, Alasfoor, D, Albittar, MI, Alegretti, MA, Aleman, AV, Alemu, ZA, Alfonso-Cristancho, R, Alhabib, S, Ali, R, Alla, F, Allebeck, P, Allen, PJ, AlMazroa, MA, Alsharif, U, Alvarez, E, Alvis-Guzman, N, Ameli, O, Amini, H, Ammar, W, Anderson, BO, Anderson, HR, Antonio, CAT, Anwari, P, Apfel, H, Arsenijevic, VSA, Artaman, A, Asghar, RJ, Assadi, R, Atkins, LS, Atkinson, C, Badawi, A, Bahit, MC, Bakfalouni, T, Balakrishnan, K, Balalla, S, Banerjee, A, Barker-Collo, SL, Barquera, S, Barregard, L, Barrero, LH, Basu, S, Basu, A, Baxter, A, Beardsley, J, Bedi, N, Beghi, E, Bekele, T, Bell, ML, Benjet, C, Bennett, DA, Bensenor, IM, Benzian, H, Bernabe, E, Beyene, TJ, Bhala, N, Bhalla, A, Bhutta, Z, Bienhoff, K, Bikbov, B, Abdulhak, AB, Blore, JD, Blyth, FM, Bohensky, MA, Basara, BB, Borges, G, Bornstein, NM, Bose, D, Boufous, S, Bourne, RR, Boyers, LN, Brainin, M, Brauer, M, Brayne, CEG, Brazinova, A, Breitborde, NJK, Brenner, H, Briggs, ADM, Brooks, PM, Brown, J, Brugha, TS, Buchbinder, R, Buckle, GC, Bukhman, G, Bulloch, AG, Burch, M, Burnett, R, Cardenas, R, Cabral, NL, Campos-Nonato, IR, Campuzano, JC, Carapetis, JR, Carpenter, DO, Caso, V, Castaneda-Orjuela, CA, Catala-Lopez, F, Chadha, VK, Chang, JC, Chen, H, Chen, W, Chiang, PP, Chimed-Ochir, O, Chowdhury, R, Christensen, H, Christophi, CA, Chugh, SS, Cirillo, M, Coggeshall, M, Cohen, A, Colistro, V, Colquhoun, SM, Contreras, AG, Cooper, LT, Cooper, C, Cooperrider, K, Coresh, J, Cortinovis, M, Criqui, MH, Crump, JA, Cuevas-Nasu, L, Dandona, R, Dandona, L, Dansereau, E, Dantes, HG, Dargan, PI, Davey, G, Davitoiu, DV, Dayama, A, De La Cruz-Gongora, V, De La Vega, SF, De Leo, D, Del Pozo-Cruz, B, Dellavalle, RP, Deribe, K, Derrett, S, Des Jarlais, DC, Dessalegn, M, DeVeber, GA, Dharmaratne, SD, Diaz-Torne, C, Ding, EL, Dokova, K, Dorsey, ER, Driscoll, TR, Duber, H, Durrani, AM, Edmond, KM, Ellenbogen, RG, Endres, M, Ermakov, SP, Eshrati, B, Esteghamati, A, Estep, K, Fahimi, S, Farzadfar, F, Fay, DFJ, Felson, DT, Fereshtehnejad, SM, Fernandes, JG, Ferri, CP, Flaxman, A, Foigt, N, Foreman, KJ, Fowkes, FGR, Franklin, RC, Furst, T, Futran, ND, Gabbe, BJ, Gankpe, FG, Garcia-Guerra, FA, Geleijnse, JM, Gessner, BD, Gibney, KB, Gillum, RF, Ginawi, IA, Giroud, M, Giussani, G, Goenka, S, Goginashvili, K, Gona, P, De Cosio, TG, Gosselin, RA, Gotay, CC, Goto, A, Gouda, HN, Guerrant, RL, Gugnani, HC, Gunnell, D, Gupta, R, Gupta, R, Gutierrez, RA, Hafezi-Nejad, N, Hagan, H, Halasa, Y, Hamadeh, RR, Hamavid, H, Hammami, M, Hankey, GJ, Hao, Y, Harb, HL, Haro, JM, Havmoeller, R, Hay, RJ, Hay, S, Hedayati, MT, Pi, IBH, Heydarpour, P, Hijar, M, Hoek, HW, Hoffman, HJ, Hornberger, JC, Hosgood, HD, Hossain, M, Hotez, PJ, Hoy, DG, Hsairi, M, Hu, H, Hu, G, Huang, JJ, Huang, C, Huiart, L, Husseini, A, Iannarone, M, Iburg, KM, Innos, K, Inoue, M, Jacobsen, KH, Jassal, SK, Jeemon, P, Jensen, PN, Jha, V, Jiang, G, Jiang, Y, Jonas, JB, Joseph, J, Juel, K, Kan, H, Karch, A, Karimkhani, C, Karthikeyan, G, Katz, R, Kaul, A, Kawakami, N, Kazi, DS, Kemp, AH, Kengne, AP, Khader, YS, Khalifa, SEAH, Khan, EA, Khan, G, Khang, YH, Khonelidze, I, Kieling, C, Kim, D, Kim, S, Kimokoti, RW, Kinfu, Y, Kinge, JM, Kissela, BM, Kivipelto, M, Knibbs, L, Knudsen, AK, Kokubo, Y, Kosen, S, Kramer, A, Kravchenko, M, Krishnamurthi, RV, Krishnaswami, S, Defo, BK, Bicer, BK, Kuipers, EJ, Kulkarni, VS, Kumar, K, Kumar, GA, Kwan, GF, Lai, T, Lalloo, R, Lam, H, Lan, Q, Lansingh, VC, Larson, H, Larsson, A, Lawrynowicz, AEB, Leasher, JL, Lee, JT, Leigh, J, Leung, R, Levi, M, Li, B, Li, Y, Li, Y, Liang, J, Lim, S, Lin, HH, Lind, M, Lindsay, MP, Lipshultz, SE, Liu, S, Lloyd, BK, Ohno, SL, Logroscino, G, Looker, KJ, Lopez, AD, Lopez-Olmedo, N, Lortet-Tieulent, J, Lotufo, PA, Low, N, Lucas, RM, Lunevicius, R, Lyons, RA, Ma, J, Ma, S, MacKay, MT, Majdan, M, Malekzadeh, R, Mapoma, CC, Marcenes, W, March, LM, Margono, C, Marks, GB, Marzan, MB, Masci, JR, Mason-Jones, AJ, Matzopoulos, RG, Mayosi, BM, Mazorodze, TT, McGill, NW, McGrath, JJ, McKee, M, McLain, A, McMahon, BJ, Meaney, PA, Mehndiratta, MM, Mejia-Rodriguez, F, Mekonnen, W, Melaku, YA, Meltzer, M, Memish, ZA, Mensah, G, Meretoja, A, Mhimbira, FA, Micha, R, Miller, TR, Mills, EJ, Mitchell, PB, Mock, CN, Moffitt, TE, Ibrahim, NM, Mohammad, KA, Mokdad, AH, Mola, GL, Monasta, L, Montico, M, Montine, TJ, Moore, AR, Moran, AE, Morawska, L, Mori, R, Moschandreas, J, Moturi, WN, Moyer, M, Mozaffarian, D, Mueller, UO, Mukaigawara, M, Murdoch, ME, Murray, J, Murthy, KS, Naghavi, P, Nahas, Z, Naheed, A, Naidoo, KS, Naldi, L, Nand, D, Nangia, V, Narayan, KMV, Nash, D, Nejjari, C, Neupane, SP, Newman, LM, Newton, CR, Ng, M, Ngalesoni, FN, Nhung, NT, Nisar, MI, Nolte, S, Norheim, OF, Norman, RE, Norrving, B, Nyakarahuka, L, Oh, IH, Ohkubo, T, Omer, SB, Opio, JN, Ortiz, A, Pandian, JD, Panelo, CIA, Papachristou, C, Park, EK, Parry, CD, Caicedo, AJP, Patten, SB, Paul, VK, Pavlin, BI, Pearce, N, Pedraza, LS, Pellegrini, CA, Pereira, DM, Perez-Ruiz, FP, Perico, N, Pervaiz, A, Pesudovs, K, Peterson, CB, Petzold, M, Phillips, MR, Phillips, D, Phillips, B, Piel, FB, Plass, D, Poenaru, D, Polanczyk, GV, Polinder, S, Pope, CA, Popova, S, Poulton, RG, Pourmalek, F, Prabhakaran, D, Prasad, NM, Qato, D, Quistberg, DA, Rafay, A, Rahimi, K, Rahimi-Movaghar, V, Rahman, SU, Raju, M, Rakovac, I, Rana, SM, Razavi, H, Refaat, A, Rehm, J, Remuzzi, G, Resnikoff, S, Ribeiro, AL, Riccio, PM, Richardson, L, Richardus, JH, Riederer, AM, Robinson, M, Roca, A, Rodriguez, A, Rojas-Rueda, D, Ronfani, L, Rothenbacher, D, Roy, N, Ruhago, GM, Sabin, N, Sacco, RL, Ksoreide, K, Saha, S, Sahathevan, R, Sahraian, MA, Sampson, U, Sanabria, JR, Sanchez-Riera, L, Santos, IS, Satpathy, M, Saunders, JE, Sawhney, M, Saylan, MI, Scarborough, P, Schoettker, B, Schneider, IJC, Schwebel, DC, Scott, JG, Seedat, S, Sepanlou, SG, Serdar, B, Servan-Mori, EE, Shackelford, K, Shaheen, A, Shahraz, S, Levy, TS, Shangguan, S, She, J, Sheikhbahaei, S, Shepard, DS, Shi, P, Shibuya, K, Shinohara, Y, Shiri, R, Shishani, K, Shiue, I, Shrime, MG, Sigfusdottir, ID, Silberberg, DH, Simard, EP, Sindi, S, Singh, JA, Singh, L, Skirbekk, V, Sliwa, K, Soljak, M, Soneji, S, Soshnikov, SS, Speyer, P, Sposato, LA, Sreeramareddy, CT, Stoeckl, H, Stathopoulou, VK, Steckling, N, Stein, MB, Stein, DJ, Steiner, TJ, Stewart, A, Stork, E, Stovner, LJ, Stroumpoulis, K, Sturua, L, Sunguya, BF, Swaroop, M, Sykes, BL, Tabb, KM, Takahashi, K, Tan, F, Tandon, N, Tanne, D, Tanner, M, Tavakkoli, M, Taylor, HR, Te Ao, BJ, Temesgen, AM, Have, MT, Tenkorang, EY, Terkawi, AS, Theadom, AM, Thomas, E, Thorne-Lyman, AL, Thrift, AG, Tleyjeh, IM, Tonelli, M, Topouzis, F, Towbin, JA, Toyoshima, H, Traebert, J, Tran, BX, Trasande, L, Trillini, M, Truelsen, T, Trujillo, U, Tsilimbaris, M, Tuzcu, EM, Ukwaja, KN, Undurraga, EA, Uzun, SB, Van Brakel, WH, Van De Vijver, S, Dingenen, RV, Van Gool, CH, Varakin, YY, Vasankari, TJ, Vavilala, MS, Veerman, LJ, Velasquez-Melendez, G, Venketasubramanian, N, Vijayakumar, L, Villalpando, S, Violante, FS, Vlassov, VV, Waller, S, Wallin, MT, Wan, X, Wang, L, Wang, J, Wang, Y, Warouw, TS, Weichenthal, S, Weiderpass, E, Weintraub, RG, Werdecker, A, Wessells, KR, Westerman, R, Wilkinson, JD, Williams, HC, Williams, TN, Woldeyohannes, SM, Wolfe, CDA, Wong, JQ, Wong, H, Woolf, AD, Wright, JL, Wurtz, B, Xu, G, Yang, G, Yano, Y, Yenesew, MA, Yentur, GK, Yip, P, Yonemoto, N, Yoon, SJ, Younis, M, Yu, C, Kim, KY, Zaki, MES, Zhang, Y, Zhao, Z, Zhao, Y, Zhu, J, Zonies, D, Zunt, JR, Salomon, JA & Murray, CJL 2015, 'Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013', Lancet, vol. 386, no. 9995, pp. 743-800. https://doi.org/10.1016/S0140-6736(15)60692-4
Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. / Vos, Theo; Barber, Ryan M.; Bell, Brad et al.
In: Lancet, Vol. 386, No. 9995, 22.08.2015, p. 743-800.
Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013
T2 - A systematic analysis for the Global Burden of Disease Study 2013
AU - Vos, Theo
AU - Barber, Ryan M.
AU - Bell, Brad
AU - Bertozzi-Villa, Amelia
AU - Biryukov, Stan
AU - Bolliger, Ian
AU - Charlson, Fiona
AU - Davis, Adrian
AU - Degenhardt, Louisa
AU - Dicker, Daniel
AU - Duan, Leilei
AU - Erskine, Holly
AU - Feigin, Valery L.
AU - Ferrari, Alize J.
AU - Fitzmaurice, Christina
AU - Fleming, Thomas
AU - Graetz, Nicholas
AU - Guinovart, Caterina
AU - Haagsma, Juanita
AU - Hansen, Gillian M.
AU - Hanson, Sarah Wulf
AU - Heuton, Kyle R.
AU - Higashi, Hideki
AU - Kassebaum, Nicholas
AU - Kyu, Hmwe
AU - Laurie, Evan
AU - Liang, Xiofeng
AU - Lofgren, Katherine
AU - Lozano, Rafael
AU - MacIntyre, Michael F.
AU - Moradi-Lakeh, Maziar
AU - Naghavi, Mohsen
AU - Nguyen, Grant
AU - Odell, Shaun
AU - Ortblad, Katrina
AU - Roberts, David Allen
AU - Roth, Gregory A.
AU - Sandar, Logan
AU - Serina, Peter T.
AU - Stanaway, Jeffrey D.
AU - Steiner, Caitlyn
AU - Thomas, Bernadette
AU - Vollset, Stein Emil
AU - Whiteford, Harvey
AU - Wolock, Timothy M.
AU - Ye, Pengpeng
AU - Zhou, Maigeng
AU - Ãvila, Marco A.
AU - Aasvang, Gunn Marit
AU - Abbafati, Cristiana
AU - Ozgoren, Ayse Abbasoglu
AU - Abd-Allah, Foad
AU - Aziz, Muna I.Abdel
AU - Abera, Semaw F.
AU - Aboyans, Victor
AU - Abraham, Jerry P.
AU - Abraham, Biju
AU - Abubakar, Ibrahim
AU - Abu-Raddad, Laith J.
AU - Abu-Rmeileh, Niveen M.E.
AU - Aburto, Tania C.
AU - Achoki, Tom
AU - Ackerman, Ilana N.
AU - Adelekan, Ademola
AU - Ademi, Zanfina
AU - Adou, Arsène K.
AU - Adsuar, Josef C.
AU - Arnlov, Johan
AU - Agardh, Emilie E.
AU - Al Khabouri, Mazin J.
AU - Alam, Sayed Saidul
AU - Alasfoor, Deena
AU - Albittar, Mohammed I.
AU - Alegretti, Miguel A.
AU - Aleman, Alicia V.
AU - Alemu, Zewdie A.
AU - Alfonso-Cristancho, Rafael
AU - Alhabib, Samia
AU - Ali, Raghib
AU - Alla, Francois
AU - Allebeck, Peter
AU - Allen, Peter J.
AU - AlMazroa, Mohammad Abdulaziz
AU - Alsharif, Ubai
AU - Alvarez, Elena
AU - Alvis-Guzman, Nelson
AU - Ameli, Omid
AU - Amini, Heresh
AU - Ammar, Walid
AU - Anderson, Benjamin O.
AU - Anderson, H. Ross
AU - Antonio, Carl Abelardo T.
AU - Anwari, Palwasha
AU - Apfel, Henry
AU - Arsenijevic, Valentain S.Arsic
AU - Artaman, Al
AU - Asghar, Rana J.
AU - Assadi, Reza
AU - Atkins, Lydia S.
AU - Atkinson, Charles
AU - Badawi, Alaa
AU - Bahit, Maria C.
AU - Bakfalouni, Talal
AU - Balakrishnan, Kalpana
AU - Balalla, Shivanthi
AU - Banerjee, Amitava
AU - Barker-Collo, Suzanne L.
AU - Barquera, Simon
AU - Barregard, Lars
AU - Barrero, Lope H.
AU - Basu, Sanjay
AU - Basu, Arindam
AU - Baxter, Amanda
AU - Beardsley, Justin
AU - Bedi, Neeraj
AU - Beghi, Ettore
AU - Bekele, Tolesa
AU - Bell, Michelle L.
AU - Benjet, Corina
AU - Bennett, Derrick A.
AU - Bensenor, Isabela M.
AU - Benzian, Habib
AU - Bernabe, Eduardo
AU - Beyene, Tariku J.
AU - Bhala, Neeraj
AU - Bhalla, Ashish
AU - Bhutta, Zulfiqar
AU - Bienhoff, Kelly
AU - Bikbov, Boris
AU - Abdulhak, Aref Bin
AU - Blore, Jed D.
AU - Blyth, Fiona M.
AU - Bohensky, Megan A.
AU - Basara, Berrak Bora
AU - Borges, Guilherme
AU - Bornstein, Natan M.
AU - Bose, Dipan
AU - Boufous, Soufiane
AU - Bourne, Rupert R.
AU - Boyers, Lindsay N.
AU - Brainin, Michael
AU - Brauer, Michael
AU - Brayne, Carol E.G.
AU - Brazinova, Alexandra
AU - Breitborde, Nicholas J.K.
AU - Brenner, Hermann
AU - Briggs, Adam D.M.
AU - Brooks, Peter M.
AU - Brown, Jonathan
AU - Brugha, Traolach S.
AU - Buchbinder, Rachelle
AU - Buckle, Geoffrey C.
AU - Bukhman, Gene
AU - Bulloch, Andrew G.
AU - Burch, Michael
AU - Burnett, Richard
AU - Cardenas, Rosario
AU - Cabral, Norberto L.
AU - Campos-Nonato, Ismael R.
AU - Campuzano, Julio C.
AU - Carapetis, Jonathan R.
AU - Carpenter, David O.
AU - Caso, Valeria
AU - Castaneda-Orjuela, Carlos A.
AU - Catala-Lopez, Ferran
AU - Chadha, Vineet K.
AU - Chang, Jung Chen
AU - Chen, Honglei
AU - Chen, Wanqing
AU - Chiang, Peggy P.
AU - Chimed-Ochir, Odgerel
AU - Chowdhury, Rajiv
AU - Christensen, Hanne
AU - Christophi, Costas A.
AU - Chugh, Sumeet S.
AU - Cirillo, Massimo
AU - Coggeshall, Megan
AU - Cohen, Aaron
AU - Colistro, Valentina
AU - Colquhoun, Samantha M.
AU - Contreras, Alejandra G.
AU - Cooper, Leslie T.
AU - Cooper, Cyrus
AU - Cooperrider, Kimberly
AU - Coresh, Josef
AU - Cortinovis, Monica
AU - Criqui, Michael H.
AU - Crump, John A.
AU - Cuevas-Nasu, Lucia
AU - Dandona, Rakhi
AU - Dandona, Lalit
AU - Dansereau, Emily
AU - Dantes, Hector G.
AU - Dargan, Paul I.
AU - Davey, Gail
AU - Davitoiu, Dragos V.
AU - Dayama, Anand
AU - De La Cruz-Gongora, Vanessa
AU - De La Vega, Shelley F.
AU - De Leo, Diego
AU - Del Pozo-Cruz, Borja
AU - Dellavalle, Robert P.
AU - Deribe, Kebede
AU - Derrett, Sarah
AU - Des Jarlais, Don C.
AU - Dessalegn, Muluken
AU - DeVeber, Gabrielle A.
AU - Dharmaratne, Samath D.
AU - Diaz-Torne, Cesar
AU - Ding, Eric L.
AU - Dokova, Klara
AU - Dorsey, E. R.
AU - Driscoll, Tim R.
AU - Duber, Herbert
AU - Durrani, Adnan M.
AU - Edmond, Karen M.
AU - Ellenbogen, Richard G.
AU - Endres, Matthias
AU - Ermakov, Sergey P.
AU - Eshrati, Babak
AU - Esteghamati, Alireza
AU - Estep, Kara
AU - Fahimi, Saman
AU - Farzadfar, Farshad
AU - Fay, Derek F.J.
AU - Felson, David T.
AU - Fereshtehnejad, Seyed Mohammad
AU - Fernandes, Jefferson G.
AU - Ferri, Cluesa P.
AU - Flaxman, Abraham
AU - Foigt, Nataliya
AU - Foreman, Kyle J.
AU - Fowkes, F. Gerry R.
AU - Franklin, Richard C.
AU - Furst, Thomas
AU - Futran, Neal D.
AU - Gabbe, Belinda J.
AU - Gankpe, Fortune G.
AU - Garcia-Guerra, Francisco A.
AU - Geleijnse, Johanna M.
AU - Gessner, Bradford D.
AU - Gibney, Katherine B.
AU - Gillum, Richard F.
AU - Ginawi, Ibrahim A.
AU - Giroud, Maurice
AU - Giussani, Giorgia
AU - Goenka, Shifalika
AU - Goginashvili, Ketevan
AU - Gona, Philimon
AU - De Cosio, Teresita Gonzalez
AU - Gosselin, Richard A.
AU - Gotay, Carolyn C.
AU - Goto, Atsushi
AU - Gouda, Hebe N.
AU - Guerrant, Richard L.
AU - Gugnani, Harish C.
AU - Gunnell, David
AU - Gupta, Rajeev
AU - Gupta, Rahul
AU - Gutierrez, Reyna A.
AU - Hafezi-Nejad, Nima
AU - Hagan, Holly
AU - Halasa, Yara
AU - Hamadeh, Randah R.
AU - Hamavid, Hannah
AU - Hammami, Mouhanad
AU - Hankey, Graeme J.
AU - Hao, Yuantao
AU - Harb, Hilda L.
AU - Haro, Josep Maria
AU - Havmoeller, Rasmus
AU - Hay, Roderick J.
AU - Hay, Simon
AU - Hedayati, Mohammad T.
AU - Pi, Ileana B.Heredia
AU - Heydarpour, Pouria
AU - Hijar, Martha
AU - Hoek, Hans W.
AU - Hoffman, Howard J.
AU - Hornberger, John C.
AU - Hosgood, H. Dean
AU - Hossain, Mazeda
AU - Hotez, Peter J.
AU - Hoy, Damian G.
AU - Hsairi, Mohamed
AU - Hu, Howard
AU - Hu, Guoqing
AU - Huang, John J.
AU - Huang, Cheng
AU - Huiart, Laetitia
AU - Husseini, Abdullatif
AU - Iannarone, Marissa
AU - Iburg, Kim M.
AU - Innos, Kaire
AU - Inoue, Manami
AU - Jacobsen, Kathryn H.
AU - Jassal, Simerjot K.
AU - Jeemon, Panniyammakal
AU - Jensen, Paul N.
AU - Jha, Vivekanand
AU - Jiang, Guohong
AU - Jiang, Ying
AU - Jonas, Jost B.
AU - Joseph, Jonathan
AU - Juel, Knud
AU - Kan, Haidong
AU - Karch, Andre
AU - Karimkhani, Chante
AU - Karthikeyan, Ganesan
AU - Katz, Ronit
AU - Kaul, Anil
AU - Kawakami, Norito
AU - Kazi, Dhruv S.
AU - Kemp, Andrew H.
AU - Kengne, Andre P.
AU - Khader, Yousef S.
AU - Khalifa, Shams Eldin A.H.
AU - Khan, Ejaz A.
AU - Khan, Gulfaraz
AU - Khang, Young Ho
AU - Khonelidze, Irma
AU - Kieling, Christian
AU - Kim, Daniel
AU - Kim, Sungroul
AU - Kimokoti, Ruth W.
AU - Kinfu, Yohannes
AU - Kinge, Jonas M.
AU - Kissela, Brett M.
AU - Kivipelto, Miia
AU - Knibbs, Luke
AU - Knudsen, Ann Kristin
AU - Kokubo, Yoshihiro
AU - Kosen, Soewarta
AU - Kramer, Alexander
AU - Kravchenko, Michael
AU - Krishnamurthi, Rita V.
AU - Krishnaswami, Sanjay
AU - Defo, Barthelemy Kuate
AU - Bicer, Burcu Kucuk
AU - Kuipers, Ernst J.
AU - Kulkarni, Veena S.
AU - Kumar, Kaushalendra
AU - Kumar, G. Anil
AU - Kwan, Gene F.
AU - Lai, Taavi
AU - Lalloo, Ratilal
AU - Lam, Hilton
AU - Lan, Qing
AU - Lansingh, Van C.
AU - Larson, Heidi
AU - Larsson, Anders
AU - Lawrynowicz, Alicia E.B.
AU - Leasher, Janet L.
AU - Lee, Jong Tae
AU - Leigh, James
AU - Leung, Ricky
AU - Levi, Miriam
AU - Li, Bin
AU - Li, Yichong
AU - Li, Yongmei
AU - Liang, Juan
AU - Lim, Stephen
AU - Lin, Hsien Ho
AU - Lind, Margaret
AU - Lindsay, M. Patrice
AU - Lipshultz, Steven E.
AU - Liu, Shiwei
AU - Lloyd, Belinda K.
AU - Ohno, Summer Lockett
AU - Logroscino, Giancarlo
AU - Looker, Katharine J.
AU - Lopez, Alan D.
AU - Lopez-Olmedo, Nancy
AU - Lortet-Tieulent, Joannie
AU - Lotufo, Paulo A.
AU - Low, Nicola
AU - Lucas, Robyn M.
AU - Lunevicius, Raimundas
AU - Lyons, Ronan A.
AU - Ma, Jixiang
AU - Ma, Stefan
AU - MacKay, Mark T.
AU - Majdan, Marek
AU - Malekzadeh, Reza
AU - Mapoma, Christopher C.
AU - Marcenes, Wagner
AU - March, Lyn M.
AU - Margono, Chris
AU - Marks, Guy B.
AU - Marzan, Melvin B.
AU - Masci, Joseph R.
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N1 - Publisher Copyright:© 2015 Elsevier Ltd.
PY - 2015/8/22
Y1 - 2015/8/22
N2 - Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
AB - Background Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies. In the Global Burden of Disease Study 2013 (GBD 2013), we estimated these quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013. Methods Estimates were calculated for disease and injury incidence, prevalence, and YLDs using GBD 2010 methods with some important refinements. Results for incidence of acute disorders and prevalence of chronic disorders are new additions to the analysis. Key improvements include expansion to the cause and sequelae list, updated systematic reviews, use of detailed injury codes, improvements to the Bayesian meta-regression method (DisMod-MR), and use of severity splits for various causes. An index of data representativeness, showing data availability, was calculated for each cause and impairment during three periods globally and at the country level for 2013. In total, 35 620 distinct sources of data were used and documented to calculated estimates for 301 diseases and injuries and 2337 sequelae. The comorbidity simulation provides estimates for the number of sequelae, concurrently, by individuals by country, year, age, and sex. Disability weights were updated with the addition of new population-based survey data from four countries. Findings Disease and injury were highly prevalent; only a small fraction of individuals had no sequelae. Comorbidity rose substantially with age and in absolute terms from 1990 to 2013. Incidence of acute sequelae were predominantly infectious diseases and short-term injuries, with over 2 billion cases of upper respiratory infections and diarrhoeal disease episodes in 2013, with the notable exception of tooth pain due to permanent caries with more than 200 million incident cases in 2013. Conversely, leading chronic sequelae were largely attributable to non-communicable diseases, with prevalence estimates for asymptomatic permanent caries and tension-type headache of 2·4 billion and 1·6 billion, respectively. The distribution of the number of sequelae in populations varied widely across regions, with an expected relation between age and disease prevalence. YLDs for both sexes increased from 537·6 million in 1990 to 764·8 million in 2013 due to population growth and ageing, whereas the age-standardised rate decreased little from 114·87 per 1000 people to 110·31 per 1000 people between 1990 and 2013. Leading causes of YLDs included low back pain and major depressive disorder among the top ten causes of YLDs in every country. YLD rates per person, by major cause groups, indicated the main drivers of increases were due to musculoskeletal, mental, and substance use disorders, neurological disorders, and chronic respiratory diseases; however HIV/AIDS was a notable driver of increasing YLDs in sub-Saharan Africa. Also, the proportion of disability-adjusted life years due to YLDs increased globally from 21·1% in 1990 to 31·2% in 2013. Interpretation Ageing of the world's population is leading to a substantial increase in the numbers of individuals with sequelae of diseases and injuries. Rates of YLDs are declining much more slowly than mortality rates. The non-fatal dimensions of disease and injury will require more and more attention from health systems. The transition to non-fatal outcomes as the dominant source of burden of disease is occurring rapidly outside of sub-Saharan Africa. Our results can guide future health initiatives through examination of epidemiological trends and a better understanding of variation across countries.
UR - http://www.scopus.com/inward/record.url?scp=84940447040&partnerID=8YFLogxK
U2 - 10.1016/S0140-6736(15)60692-4
DO - 10.1016/S0140-6736(15)60692-4
M3 - 学術論文
C2 - 26063472
AN - SCOPUS:84940447040
SN - 0140-6736
VL - 386
SP - 743
EP - 800
JO - Lancet
JF - Lancet
IS - 9995
ER -
Vos T, Barber RM, Bell B, Bertozzi-Villa A, Biryukov S, Bolliger I et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015 Aug 22;386(9995):743-800. doi: 10.1016/S0140-6736(15)60692-4